CAS:556813-39-9|CHIR-98014

Catalogue Number:C292100
Chemical Name:CHIR-98014
Synonyms:N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-
CAS Number:556813-39-9
Molecular Formula:C₂₀H₁₇Cl₂N₉O₂
Appearance:Yellow Solid
Melting Point:192-196°C (dec.)
Molecular Weight:486.31
Storage:4°C
Solubility:DMSO, Methanol
Category:Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:A glycogen synthase kinase-3 (GSK-3) inhibitor. Effects of GSK inhibitors on p-tau, GSK-3b activities and cell death were measured in a human neuronal cell line (LUHMES). Lithium and CHIR98014 reduced tau phosphorylation (Ser396) in the cortex and hippocampus. Inhibition of GSK-3 is recently regarded as one of the viable approaches to therapy for Alzheimer’s disease, cancer, diabetes mellitus, osteoporosis, and bipolar mood disorder.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References:Aardema, M., et al.: Mutat. Res., 410, 3
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