CAS:37744-65-3|(2S)-4′-Depropyl-4′-propylidenelincomycin (Mixture of Diastereomers)

Catalogue Number:D281915
Chemical Name:(2S)-4′-Depropyl-4′-propylidenelincomycin (Mixture of Diastereomers)
Synonyms:Lincomycin EP Impurity B, Methyl 6,8-Dideoxy-6-[[[(2S)-1-methyl-4-propylidene-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-?-D-galacto-octopyranoside; Methyl (2S)-6,8-Dideoxy-6-[[(1-methyl-4-propylidene-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-erythro-?-D-galacto-octopyranoside; (S)-N-((1R,2R)-2-Hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylidenepyrrolidine-2-carboxamide; 4′-Depropyl-4′-propylidenelincomycin
CAS Number:37744-65-3
Molecular Formula:C₁₈H₃₂N₂O₆S
Appearance:White to Off-White Solid
Melting Point:89-94C
Molecular Weight:404.52
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Stability
Light Sensitive
Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; Carbohydrates and Oligosaccharides;
Applications:(2S)-4′-Depropyl-4′-propylidenelincomycin is an impurity of Lincomycin (L466200), an antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
References:Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962); Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964); Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994)
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