DM4-d6

Chemical Name:DM4-d6
Synonyms:N2′-Deacetyl-N2′-(4-mercapto-4-methyl-1-oxopentyl)-maytansine-d6; Maytansinoid DM4-d6
Alternate CAS #:796073-69-3
Molecular Formula:C₃₈H₄₈D₆ClN₃O₁₀S
Molecular Weight:786.4
Category:Building Blocks; Chiral Molecules; Isotopic Labeled Analogues;
Applications:DM4-d6 is an isotopically labelled analog of 2′-Deacetyl-N2′-(4-mercapto-4-methyl-1-oxopentyl)-maytansine (D198090), which is an intermediate used to prepare semisynthetic maytansine analogs which can be conjugated with antibodies for targeted treatment of cancer.
References:Erickson, H., et. al.: Cancer Res., 66, 4426 (2006);Widdison, W., et al.: J. Med. Chem., 49, 4392 (2006)
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